Natural Products as Aromatase Inhibitors

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Natural Products as Aromatase Inhibitors



Anti-Cancer Agents in Medicinal Chemistry, 8(6): 646-682.

Author(s): Marcy J. Balunas, Bin Su, Robert W. Brueggemeier and A Douglas Kinghorn.

Affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

Abstract

With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.

Keywords:

Aromatase inhibitors, natural products, breast cancer, botanical dietary supplements.



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Article Details

Volume: 8
Issue Number: 6
First Page: 646
Last Page: 682
Page Count: 37
DOI: 10.2174/187152008785133092
Price: $58
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