Targeting Inhibitor of Apoptosis Proteins (IAPs) for Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Targeting Inhibitor of Apoptosis Proteins (IAPs) for Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry, 8(5): 533-539.

Author(s): Simone Fulda.

Affiliation: University Children's Hospital,Eythstr. 24,D-89075 Ulm, Germany.


Since cell death by apoptosis plays a key role in the regulation of tissue homeostasis, dysregulation of the cells intrinsic death program may foster tumor formation and progression. “Inhibitor of apoptosis proteins” (IAPs) block apoptosis at the core of the apoptotic machinery by inhibiting effector caspases. Aberrant expression and/or function of IAPs are found in many human cancers and have been implied in resistance to current treatment approaches. Recent insights into the role of IAPs have provided the basis for various exciting discoveries that aim at modulating expression or function of IAPs. Thus, targeting IAPs, e.g. by antisense approaches or small molecule inhibitors, presents a promising novel approach for future drug development and may proof to be a successful strategy to overcome apoptosis resistance of human cancers.


Apoptosis, cancer, IAPs, Smac.

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Article Details

Volume: 8
Issue Number: 5
First Page: 533
Last Page: 539
Page Count: 7
DOI: 10.2174/187152008784533107
Price: $58

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