Repair and Translesion DNA Polymerases as Anticancer Drug Targets

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Repair and Translesion DNA Polymerases as Anticancer Drug Targets



Anti-Cancer Agents in Medicinal Chemistry, 8(4): 431-447.

Author(s): Giovanni Maga and Ulrich Hubscher.

Affiliation: Ulrich Hubscher, Institute for Veterinary Biochemistry and Molecular Biology, University of Zurich-Irchel, Winterthurerstrasse 190, CH-8057 Zurich Switzerland.

Abstract

We have very recently highlighted possible connections between DNA polymerases, the main enzymes in the DNA metabolism, and human diseases (Ramadan, K., Maga, G. and Hubscher, U.: DNA polymerases and diseases, In: Genome Integrity: Facets and Perspectives ed. Lankenau, D.-H. Springer Verlag, Heidelberg Germany, Vol 1, pp. 69-102, 2007). Beside a role in DNA replication of the genome DNA polymerases have fundamental functions in other aspect of DNA metabolism, such as DNA repair, DNA recombination, translesion DNA synthesis and cell cycle checkpoint. In the last decade many novel DNA polymerases have been identified, but their exact cellular functions still await clarification. We know that many DNA polymerases have redundant functions. It is a fact that specific inhibition of certain DNA polymerases is a promising approach to develop anticancer drugs. In this review we will concentrate on DNA repair proteins and translesion DNA polymerases as possible targets for anti cancer drugs.

Keywords:

DNA replication, DNA repair, DNA polymerase, translesion synthesis, DNA damage tolerance, cancer, anticancer therapy, medicinal chemistry.



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Article Details

Volume: 8
Issue Number: 4
First Page: 431
Last Page: 447
Page Count: 17
DOI: 10.2174/187152008784220348
Price: $58
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