Helicases as Prospective Targets for Anti-Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Helicases as Prospective Targets for Anti-Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 8(4): 390-401.

Author(s): Rigu Gupta, Robert M. Brosh and Jr.

Affiliation: Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive,Baltimore, MD 21224 USA.

Abstract

It has been proposed that selective inactivation of a DNA repair pathway may enhance anti-cancer therapies that eliminate cancerous cells through the cytotoxic effects of DNA damaging agents or radiation. Given the unique and critically important roles of DNA helicases in the DNA damage response, DNA repair, and maintenance of genomic stability, a number of strategies currently being explored or in use to combat cancer may be either mediated or enhanced through the modulation of helicase function. The focus of this review will be to examine the roles of helicases in DNA repair that might be suitably targeted by cancer therapeutic approaches. Treatment of cancers with anti-cancer drugs such as small molecule compounds that modulate helicase expression or function is a viable approach to selectively kill cancer cells through the inactivation of helicase-dependent DNA repair pathways, particularly those associated with DNA recombination, replication restart, and cell cycle checkpoint.

Keywords:

Helicase, chemotherapy, anti-cancer drug, DNA repair, genomic instability, cancer, RecQ, Fanconi anemia, Werner syndrome.



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Article Details

Volume: 8
Issue Number: 4
First Page: 390
Last Page: 401
Page Count: 12
DOI: 10.2174/187152008784220339
Price: $58
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