Caspase Activity Modulators as Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Caspase Activity Modulators as Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry, 8(3): 322-341.

Author(s): Ilya Okun, Konstantin V. Balakin, Sergey E. Tkachenko and Alexandre V Ivachtchenko.

Affiliation: ChemDiv, Inc. 6605 Nancy Ridge Dr. San Diego, CA 92121, USA.


Proteolytic caspase enzymes play a central role in cell apoptosis, or programmed cell death, often as integrating elements of different stimuli leading to the cell death. Since blockade of apoptotic pathways are fundamental for cell survival and proliferation, particularly in cancer cells, the activation of caspases is an attractive target for anticancer therapy. This review describes some of the druggable therapeutic targets thus far identified within the core apoptotic machinery, the corresponding drugs that have been developed, their effects on caspase-dependent apoptotic pathways and their potential impact on the therapy of cancer. With several successful anticancer drugs on the market and numerous compounds in preclinical and clinical developments, modulators of caspase-dependent apoptotic pathways belong to the most important category of anticancer agents.


Caspase, inhibitors, apoptosis, cancer, drugs.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 8
Issue Number: 3
First Page: 322
Last Page: 341
Page Count: 20
DOI: 10.2174/187152008783961914
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science