Glycoconjugates in Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Glycoconjugates in Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry, 8(1): 92-121.

Author(s): Laura Cipolla, Francesco Peri and Cristina Airoldi.

Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, della Scienza 2, 20126 Milano-Italy.


This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is elicited by the association in the same molecule a carbohydrate, as B-cell antigen, and a peptide, or an entire protein, as T-cell epitope. We will review on the synthesis and the immunological investigation of various glycoconjugates presenting tumor-associated carbohydrate antigens. Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential antitumour therapeutics will be considered.


Glycopeptides, glyconanoparticles, tumour-associated carbohydrate antigens, glycoconjugates, anti-tumour vaccines.

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Article Details

Volume: 8
Issue Number: 1
First Page: 92
Last Page: 121
Page Count: 30
DOI: 10.2174/187152008783330815

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