Role of Focal Adhesion Kinase in Human Cancer: A Potential Target for Drug Discovery

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Role of Focal Adhesion Kinase in Human Cancer: A Potential Target for Drug Discovery

Anti-Cancer Agents in Medicinal Chemistry, 7(6): 681-684.

Author(s): Edward Kyu-Ho Han and Thomas McGonigal.

Affiliation: Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, Dept. R47S, Bldg.AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA.


The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to the points of cell contact with the extracellular matrix, called focal adhesions. FAK is involved in several cellular processes including invasion, motility, proliferation and apoptosis. In in vivo animal studies, FAK has been shown to contribute to tumor development and malignancy. Furthermore, FAK expression was shown to be elevated in a number of human cancers. Increased FAK expression and activity are correlated with malignant phenotype and poor prognosis in patients. Taken together, these studies suggest that FAK is a potentially good target for drug discovery. In this review, FAK and its relationship to cancer, as well as approaches to therapeutic intervention of FAK will be discussed.


Focal adhesion kinase (FAK), tumor, siRNA, small molecule inhibitors, FAK expression.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 7
Issue Number: 6
First Page: 681
Last Page: 684
Page Count: 4
DOI: 10.2174/187152007784111296
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science