Non-Receptor Tyrosine Kinase Inhibitors in Lung Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Non-Receptor Tyrosine Kinase Inhibitors in Lung Cancer



Anti-Cancer Agents in Medicinal Chemistry, 7(6): 633-642.

Author(s): Olwen Hahn and Ravi Salgia.

Affiliation: Section of Hematology, Oncology,University of Chicago Medical Center, Pritkzer School of Medicine,5841 S Maryland Ave, MC 2115, Chicago, Il 60637, USA.

Abstract

Lung cancer is a leading cause of cancer death. Systemic therapies with cytotoxic chemotherapies remain ineffective. Current research efforts in lung cancer have focused on developing novel agents to target cellular pathways that are altered in lung cancer. Protein tyrosine kinases are a family of oncogenes that regulate important cellular processes such as differentiation, proliferation, cell cycle, motility, and apoptosis. In this article, we review non receptor tyrosine kinases ’ role in lung cancer and the development of agents that target these proteins.

Keywords:

Lung cancer, non receptor tyrosine kinase inhibitors, novel targets.



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Article Details

Volume: 7
Issue Number: 6
First Page: 633
Last Page: 642
Page Count: 10
DOI: 10.2174/187152007784111322
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