Brutons Tyrosine Kinase as a New Therapeutic Target

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Brutons Tyrosine Kinase as a New Therapeutic Target

Anti-Cancer Agents in Medicinal Chemistry, 7(6): 624-632.

Author(s): Fatih M. Uckun, Heather E. Tibbles and Alexei O Vassilev.

Affiliation: Parker Hughes Cancer Center,2848 Patton Road, St. Paul, MN 55113, USA.


Targeting Brutons tyrosine kinase (BTK) with a small molecule inhibitor may be useful in treatment of BTK-expressing malignancies because of the anti-apoptotic function of BTK in cancer cells. Furthermore, BTK inhibitors also exhibit anti-thrombotic properties that may be desirable in the context of the increased risk of thromboembolic complications in cancer patients. This review will focus on the role of BTK in drug resistance in cancer, thromboembolism, and various pathologic immune responses, such as graft versus host disease. The therapeutic potential of targeting BTK is illustrated by discussion of the biologic activity profile of the rationally designed BTK inhibitor LFM-A13.


Rational drug design, tyrosine kinases, BTK, cancer, thromboembolism.

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Article Details

Volume: 7
Issue Number: 6
First Page: 624
Last Page: 632
Page Count: 9
DOI: 10.2174/187152007784111331
Price: $58

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