Recent Progress in Discovery and Development of Antimitotic Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Recent Progress in Discovery and Development of Antimitotic Agents



Anti-Cancer Agents in Medicinal Chemistry, 7(2): 189-208.

Author(s): Alex Kiselyov, Konstantin V. Balakin, Sergey E. Tkachenko, Nikolay Savchuk and Alexandre V Ivachtchenko.

Affiliation: ChemDiv, Inc. 11558 Sorrento Valley Rd., Ste. 5, San Diego, CA 92121, USA.

Abstract

This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.

Keywords:

antimitotic agent, inhibitor of tubulin polymerization, microtubule-stabilizing agent, mitotic kinesin, mitotic kinase.



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Article Details

Volume: 7
Issue Number: 2
First Page: 189
Last Page: 208
Page Count: 20
DOI: 10.2174/187152007780058650
Price: $58
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