Biochemical Mechanisms of Cisplatin Cytotoxicity

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Biochemical Mechanisms of Cisplatin Cytotoxicity

Anti-Cancer Agents in Medicinal Chemistry, 7(1): 3-18.

Author(s): Victoria Cepeda, Miguel A. Fuertes, Josefina Castilla, Carlos Alonso, Celia Quevedo and Jose M Perez.

Affiliation: Departmento de Quimica Inorganica, Facultad de Ciencias, Universidad Autonoma de Madrid, 28949-Spain.


Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35 years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have enjoyed a huge clinical and commercial hit. Ever since the initial discovery of the anticancer activity of cisplatin, major efforts have been devoted to elucidate the biochemical mechanisms of antitumor activity of cisplatin in order to be able to rationally design novel platinum based drugs with superior pharmacological profiles. In this report we attempt to provide a current picture of the known facts pertaining to the mechanism of action of the drug, including those involved in drug uptake, DNA damage signals transduction, and cell death through apoptosis or necrosis. A deep knowledge of the biochemical mechanisms, which are triggered in the tumor cell in response to cisplatin injury not only may lead to the design of more efficient platinum antitumor drugs but also may provide new therapeutic strategies based on the biochemical modulation of cisplatin activity.


Cisplatin, cancer, DNA, apoptosis, necrosis.

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Article Details

Volume: 7
Issue Number: 1
First Page: 3
Last Page: 18
Page Count: 16
DOI: 10.2174/187152007779314044

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