Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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5 - Year: 2.849

Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis

Anti-Cancer Agents in Medicinal Chemistry, 6(5): 461-468.

Author(s): Shanavas Alikunju and Sivaram Pillarisetti.

Affiliation: Discovery Research, Dr. Reddy's Laboratories and Reddy US Therapeutics Inc. Norcross, GA 30071, USA.


Despite many recent advances the prognosis of cancer patients with metastasis still remains poor. In metastatic invasion, tumor cells interact with endothelial cells through several distinct adhesion molecules. Adherent tumor cells extravasate into tissues by degrading basement membranes with matrix degrading enzymes such as heparanases and matrix metalloproteinases. Endothelial expression of matrix degrading enzymes and adhesion molecules are under the control of inflammatory cytokines. These inflammatory proteins and the signaling pathways involved in the expression of these genes are under intense investigation as therapeutic targets to prevent tumor growth and metastasis. The current review focuses on selected players of the inflammation cascade and drugs that target these inflammatory genes.


Cancer, Cytokines, Inflammation, Metastasis, Proteoglycans, TNF.

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Article Details

Volume: 6
Issue Number: 5
First Page: 461
Last Page: 468
Page Count: 8
DOI: 10.2174/187152006778226477
Price: $58

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