Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis



Anti-Cancer Agents in Medicinal Chemistry, 6(5): 461-468.

Author(s): Shanavas Alikunju and Sivaram Pillarisetti.

Affiliation: Discovery Research, Dr. Reddy's Laboratories and Reddy US Therapeutics Inc. Norcross, GA 30071, USA.

Abstract

Despite many recent advances the prognosis of cancer patients with metastasis still remains poor. In metastatic invasion, tumor cells interact with endothelial cells through several distinct adhesion molecules. Adherent tumor cells extravasate into tissues by degrading basement membranes with matrix degrading enzymes such as heparanases and matrix metalloproteinases. Endothelial expression of matrix degrading enzymes and adhesion molecules are under the control of inflammatory cytokines. These inflammatory proteins and the signaling pathways involved in the expression of these genes are under intense investigation as therapeutic targets to prevent tumor growth and metastasis. The current review focuses on selected players of the inflammation cascade and drugs that target these inflammatory genes.

Keywords:

Cancer, Cytokines, Inflammation, Metastasis, Proteoglycans, TNF.



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Article Details

Volume: 6
Issue Number: 5
First Page: 461
Last Page: 468
Page Count: 8
DOI: 10.2174/187152006778226477
Price: $58
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