The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy

Anti-Cancer Agents in Medicinal Chemistry, 6(2): 111-125.

Author(s): George W. Kabalka and Min-Liang Yao.

Affiliation: Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, TN 37996-1600, USA.


The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.


isotopes, linear energy transfer (LET), 4-Dihydroxyborylphenylalanine, water-solubilizing functional group, melanoma, Bucherer-Strecker reaction.

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Article Details

Volume: 6
Issue Number: 2
First Page: 111
Last Page: 125
Page Count: 15
DOI: 10.2174/187152006776119144
Price: $58

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