Blocking the PI3K/PKB Pathway in Tumor Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Blocking the PI3K/PKB Pathway in Tumor Cells



Anti-Cancer Agents in Medicinal Chemistry, 5(5): 449-462.

Author(s): F. Stauffer, P. Holzer and C Garcia-Echeverria.

Affiliation: Novartis Institutes for Bio-Medical Research, WKL-136.4.84, CH-4002, Basel, Switzerland.

Abstract

A substantial number of experimental and epidemiological studies support an important role for the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway in the biology of human cancers. Components of this signaling cascade have been found to be deregulated in a wide range of solid tumors and hematologic malignancies, and extensive anti-cancer therapeutic programs are now devoted to the identification of agents that specifically block this molecular pathway. This article focuses on the current knowledge of the alterations of the PI3K/PKB pathway in cancer cells and ongoing drug discovery efforts to therapeutically target it. Particular emphasis is placed on medicinal chemistry activities to identify and develop compounds able to modulate the kinase activity of its main molecular components.

Keywords:

kinase inhibitors, apoptosis, targeted therapy, experimental therapeutics, lipid kinase, serine/threonine kinase, cell survival.



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Article Details

Volume: 5
Issue Number: 5
First Page: 449
Last Page: 462
Page Count: 14
DOI: 10.2174/1568011054866937
Price: $58
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