Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

Anti-Cancer Agents in Medicinal Chemistry, 4(6): 509-521.

Author(s): Michelle Prudhomme.

Affiliation: Laboratoire SEESIB, UMR 6504 CNRS, Universite Blaise Pascal, 24, Avenue des Landais, 63177 Aubiere,France.


Natural and synthetic indolocarbazole compounds have triggered considerable interest since the discovery in 1986 of the inhibitory properties of staurosporine toward protein kinase C (PKC). Later, it has been shown that indolocarbazole compounds may inhibit various kinases, such as cyclin dependent-kinases and / or topoisomerase I, someones behave only as DNA intercalators. In this review are presented various indolocarbazole compounds bearing a sugar moiety and their biological targets. The relevance of these targets to develop indolocarbazole compounds as potential antitumor agents is discussed.


indolocarbazoles, protein kinases, topoisomerase I, dna intercalators, antitumor agents.

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Article Details

Volume: 4
Issue Number: 6
First Page: 509
Last Page: 521
Page Count: 13
DOI: 10.2174/1568011043352650
Price: $58

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