Cytoprotection and Immunomodulation in Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Cytoprotection and Immunomodulation in Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 4(6): 479-490.

Author(s): Sham Diwanay, Manish Gautam and Bhushan Patwardhan.

Affiliation: Bioprospecting Laboratory,Interdisciplinary School of Health Sciences, University of Pune, Pune -411007, India.

Abstract

Bioprospecting and natural products drug development for cancer treatment has become an important area. Most of the cancer chemotherapeutic agents are associated with toxicity towards normal cells and tissues. Optimal dosing of cancer chemotherapeutic agents is often limited because of severe non-myelosuppressive and myelosuppressive toxicities. It is a continuing challenge to design therapy that is safer, effective and selective. Cytoprotective agents offer opportunities to reduce treatment related toxicity of anticancer therapy without diminution of efficacy. None of the available agents satisfy criteria for an ideal cytoprotection. This has stimulated research for discovering natural resources with immunomodulatory and cytoprotective activities. This article describes chemical agents presently employed in clinical practice and reviews ethnopharmacological agents reported to have chemoprotective, radioprotective, immunomodulating, adaptogenic and antitumour activities.

Keywords:

chemoprotection, cytoprotection, immunomodulation, radioprotection, cancer chemotherapy, ayurveda, withania somnifera.



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Article Details

Volume: 4
Issue Number: 6
First Page: 479
Last Page: 490
Page Count: 12
DOI: 10.2174/1568011043352704
Price: $58
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