Resistance in Cancer: A Target for Drug Discovery

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Resistance in Cancer: A Target for Drug Discovery



Anti-Cancer Agents in Medicinal Chemistry, 4(5): 457-460.

Author(s): Mark Searcey and Laurence H Patterson.

Affiliation: Dept of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29-39Brunswick Square, London WC1N 1AX.

Abstract

Resistance remains a major problem in the clinical utility of cancer chemotherapy. However, it also represents a tumour cell phenotype that is in many ways different, and thus distinguishable, from the majority of normal cells. Two approaches to the targeting of resistant cells are described involving intratumoral P450 expression, mechanisms of drugefflux and defective DNA repair. It is suggested that the view of the solid tumour as a complex organ rather than a collection of individual cells will inform future drug development and both overcome and target multiple resistance mechanisms.

Keywords:

non-receptor serine/threonine kinase, atp binding site, protein kinase selectivity, sti-571, bms-354825.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 4
Issue Number: 5
First Page: 457
Last Page: 460
Page Count: 4
DOI: 10.2174/1568011043352722
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science