Plant-Derived Protein Tyrosine Kinase Inhibitors as Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Plant-Derived Protein Tyrosine Kinase Inhibitors as Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry, 4(2): 173-197.

Author(s): Ferenc Hollosy and Gyorgy Keri.

Affiliation: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University. Puskin u. 9., Budapest, 1088 Hungary.


Protein tyrosine kinases play a fundamental role in signal transduction pathways regulating a number of cellular functions such as cell growth, differentiation and cell death. Tyrosine kinases are, therefore attractive targets for the design of new therapeutic agents, not only against cancer, but also against many other diseases. Numerous tyrosine kinase inhibitors have been discovered by screening of plant extracts based on ethnopharmacological and chemotaxonomical knowledge. Specific screening approaches have led to the isolation of structurally distinct classes of inhibitors, including phenylpropanes, chalcones, flavonoids, coumarins, styrenes, quinones and terpenes. These natural inhibitors have served as valuable leads for further design and synthesis of more active analogues. Many of these inhibitors have also been used in probing the molecular and cellular mechanisms involved in the protein tyrosine kinase mediated signal transduction. In this review, plant-derived protein tyrosine kinase inhibitors and their synthetic analogues were systematically evaluated based on their plant origin, structureactivity relationship and anticancer efficacy.


protein tyrosine kinase inhibitors, medicinal plants, plant secondary metabolism, drug development.

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Article Details

Volume: 4
Issue Number: 2
First Page: 173
Last Page: 197
Page Count: 25
DOI: 10.2174/1568011043482124
Price: $58

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