Targeting Human Telomerase in Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Current: 2.722
5 - Year: 2.849

Targeting Human Telomerase in Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 2(5): 577-587.

Author(s): Sylvain Huard and Chantal Autexier.

Affiliation: Department of Anatomy andCell Biology, McGill University, and Bloomfield Centre for Research inAging, Lady Davis Institute for Medical Research, The Sir Mortimer B.Davis Jewish General Hospital, 3755 Cote Ste. Catherine Road, Montreal,Quebec, CANADA, H3T 1E2

Abstract

Telomerase is a specialized RNA template-containing reverse transcriptase that mediates telomere repeat synthesis at chromosome ends. The maintenance of telomere length and integrity is essential for cell survival. Telomerase is active in most immortal and tumor cells, whereas the majority of normal human cells demonstrate no detectable activity and undergo telomere shortening. The identification of a possible role for telomerase in cellular aging and cancer has led to numerous studies designed to characterize this ribonucleoprotein enzyme. Inhibiting telomerase activity in immortal human cells reduces cellular proliferative capacity and can lead to cell death. Identifying mechanisms to specifically inhibit telomerase activity in malignant cells could thus be of great therapeutic value in the treatment of cancer. In this review, we summarize the current understanding of the mechanism of action of human telomerase. The biochemical characterization of telomerase is necessary for the design and evaluation of antitelomerase therapies. Different strategies are currently under investigation to design inhibitors that target the reverse transcriptase and RNA components of the telomerase complex. Recent advances in the design of these inhibitors and their properties are discussed.

Keywords:

Human Telomerase, Cancer Therapy, Proteins, hTERT and hTR, Antisense, Ribozymes.



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Article Details

Volume: 2
Issue Number: 5
First Page: 577
Last Page: 587
Page Count: 11
DOI: 10.2174/1568011023353822
Price: $58
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