Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Anti-Cancer Agents in Medicinal Chemistry, 15(7): 809-815.

Author(s): Lichun Sun, Guangchun Sun, Yan Yu and David H Coy.

Affiliation: Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University; 801 He-Qing Rd., Shanghai 200240, China.


Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.


Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.

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Article Details

Volume: 15
Issue Number: 7
First Page: 809
Last Page: 815
Page Count: 7
DOI: 10.2174/1871520615666150202102809
Price: $58

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