Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?



Anti-Cancer Agents in Medicinal Chemistry, 15(7): 809-815.

Author(s): Lichun Sun, Guangchun Sun, Yan Yu and David H Coy.

Affiliation: Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University; 801 He-Qing Rd., Shanghai 200240, China.

Abstract

Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.




Keywords:

Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.



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Article Details

Volume: 15
Issue Number: 7
First Page: 809
Last Page: 815
Page Count: 7
DOI: 10.2174/1871520615666150202102809
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