Recent Trends of Chalcones Potentialities as Antiproliferative and Antiresistance Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Recent Trends of Chalcones Potentialities as Antiproliferative and Antiresistance Agents

Anti-Cancer Agents in Medicinal Chemistry, 15(5): 592-604.

Author(s): Evelyn Winter, Claudriana Locatelli, Attilio Di Pietro and Tânia B Creczynski-Pasa.

Affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina P.O. Box 476, Florianópolis, SC, 88040-900, Brazil.


Chalcones are natural compounds found in plants, fruits and vegetables. This class of compounds has shown many biological activities including antioxidant, antimicrobial, anti-inflammatory, antifungal and antihypertensive, among others. In cancer, it has been reported that chalcones interfere in several points of the signal transduction pathways related to cellular proliferation, angiogenesis, metastasis, apoptosis and the reversal of multidrug resistance. The large number of research articles and patents related to chalcones is already an indication of their importance as a lead class of compounds. This article gathers recent efforts to elucidate the molecular mechanisms of action of chalcones, associated with their anticancer and anti resistance potential.


Apoptosis, cancer, chalcones, cytotoxicity, drug-efflux pump inhibitors, multidrug resistance.

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Article Details

Volume: 15
Issue Number: 5
First Page: 592
Last Page: 604
Page Count: 13
DOI: 10.2174/1871520615666150101130800
Price: $58

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