Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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5 - Year: 2.849

Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 15(5): 537-547.

Author(s): Mingming Zhang and Dianqing Sun.

Affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.

Abstract

Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β - Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β - carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.




Keywords:

Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity relationship.



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Article Details

Volume: 15
Issue Number: 5
First Page: 537
Last Page: 547
Page Count: 11
DOI: 10.2174/1871520614666141128121812
Price: $58
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