Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

Anti-Cancer Agents in Medicinal Chemistry, 15(4): 423-432.

Author(s): Shuaizhang Li, Wen Zhang, Xuejiao Yin, Shilai Xing, Heidi Qunhui Xie, Zhengyu Cao and Bin Zhao.

Affiliation: Research Center for Eco- Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.


The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.


ATP-binding cassette (ABC) transporter, cancer, inhibitors, multi-drug resistance, substrate.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Author video for this article

Watch what auhtors say about their articles

Article Details

Volume: 15
Issue Number: 4
First Page: 423
Last Page: 432
Page Count: 10
DOI: 10.2174/1871520615666150129212723
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science