Effect of two Antiandrogens as Protectors of Prostate and Brain in a Huntington`s Animal Model

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Effect of two Antiandrogens as Protectors of Prostate and Brain in a Huntington`s Animal Model



Anti-Cancer Agents in Medicinal Chemistry, 14(9): 1293-1301.

Author(s): David Calderon Guzman, Eugene Bratoeff, Alejandra Chavez Riveros, Norma Osnaya Brizuela, Gerardo Barragan Mejia, Ernestina Hernandez Garcia, Hugo Juarez Olguin and Edna Garcia Cruz.

Affiliation: Laboratorio de Farmacologia, Instituto Nacional de Pediatria, Av Iman #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico.

Abstract

The purpose of this work is to know the effect of flutamide and a novel synthetic steroid 3β-p-Iodobenzoyloxypregnan-4,16- diene-6,20-dione (IBP) on the levels of dopamine, 5-HIAA (5-hydroxyindole acetic acid), and some oxidative stress markers in animal model with Huntington disease. Thirty male Wistar rats divided in groups of 6 animals each were subjected to the following treatment: group A, 3-nitro propionic acid (3-NPA, as inducer of Huntington); group B, flutamide; group C, 3-NPA + flutamide; group D, IBP; and group E, 3-NPA + IBP. Treatment scheme for all groups were at 4 mg/kg/day administered intraperitoneally. The measurement of haemoglobin was carried out from blood while the concentrations of ATPase, 5α-reductase, reduced glutathione (GSH), calcium, H2O2, 5-HIAA, and dopamine were determined from brain and prostate tissues using validated methods. The results depicted a significant decrease of dopamine and GSH in cerebellum/Medulla oblongata of animals treated with IBP. The prostate gland of the same group of treatment also showed a significant decrease in the concentrations of TBARS, H2O2, and total ATPase. In hemispheres of groups D and E, dopamine, H2O2, and total ATPase decreased significantly while in prostate, hemispheres, and cerebellum/Medulla oblongata of groups B and C; calcium, 5α-reductase, ATPase, H2O2, and TBARS were found to witness a significant decrease. Results showed an antiandrogenic activity of flutamide, while the novel steroid IBP showed neuroprotective properties by changes on oxidative stress biomarkers as critical pathways leading to prostate and brain degeneration. Probably steroid homeostasis disequilibrium could have led to alterations in dopamine metabolism GSH in Huntington´s disease animal models.




Keywords:

Brain, oxidative biomarkers, prostate, rat, synthetic steroid.



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Article Details

Volume: 14
Issue Number: 9
First Page: 1293
Last Page: 1301
Page Count: 9
DOI: 10.2174/1871520614666141010094847
Price: $58
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