Caspases and ROS - Dependent Mechanism of Action Mediated by Combination of WP 631 and Epothilone B

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Caspases and ROS - Dependent Mechanism of Action Mediated by Combination of WP 631 and Epothilone B



Anti-Cancer Agents in Medicinal Chemistry, 14(9): 1261-1270.

Author(s): Aneta Rogalska, Barbara Bukowska and Agnieszka Marczak.

Affiliation: Department of Thermo biology, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Abstract

In this article, the synergistic effects of WP 631 and epothilone B (Epo B) combination in human ovarian cancer cells (SKOV-3) cells are investigated and the reasons for the exact mechanisms of action of both drugs co-administered are explained. Compared with single drugs, the combination treatment significantly enhances apoptosis as confirmed by increases in caspases (-8, -9, -3) activity, ROS level and DNA damage and decreases in mitochondrial membrane potential. The combination of the compounds activated both caspase - 8 and -9, indicates that both pathways of apoptosis, extrinsic (induced by the effect of Epo B) and intrinsic (triggered mainly by WP 631) participate in the proposed treatment. Thus, the results of this study strongly suggest a synergistic action of the combined treatment with WP 631 and Epo B in SKOV-3 cells death induction.




Keywords:

Apoptosis, epothilone B, ovarian cancer, synergism, WP 631.



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Article Details

Volume: 14
Issue Number: 9
First Page: 1261
Last Page: 1270
Page Count: 10
DOI: 10.2174/1871520614666140608150807
Price: $58
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