Therapeutic Targeting of Malignant Glioma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Therapeutic Targeting of Malignant Glioma



Anti-Cancer Agents in Medicinal Chemistry, 14(8): 1075-1084.

Author(s): Daniela Alexandru-Abrams, Martin R. Jadus, Frank P. Hsu, Apostolos Stathopoulos and Daniela A Bota.

Affiliation: University of California, Irvine, Shanbrom Hall, Suite 121, Mail Code: 4280, Irvine, CA 92697.

Abstract

Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of differention. Evidence indicated that recurrence is due to a development or persistance of a subpopulation of these tumor cells which are inherently resistant to treatment and these were defined as the glioma stem-like cells (GSC). It is hypothesized that GSC become highly malignant by accumulating mutations in oncogenic pathways. These cells present with specific surface markers which helps identify them. Targeting the surface markers as well as the signaling pathways of GSCs has been an ongoing research effort. This review focuses on summarizing the current treatment modalities used to glioblastoma treatments, evaluating their efficacy in controlling and eradicatig the GSCs, discussing the machanisms involved in GSC tumor proliferation and resistance to treatments in addition to proposing potential avenues to target GSCs in order to provide a potential cure for this cancer.




Keywords:

chemotherapy, glioma stem cells, immunotherapy, malignant glioma, treatment resistance.



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Article Details

Volume: 14
Issue Number: 8
First Page: 1075
Last Page: 1084
Page Count: 10
DOI: 10.2174/1871520614666140825105145
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