Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview

Anti-Cancer Agents in Medicinal Chemistry, 14(7): 936-945.

Author(s): Dorina Gheorgheosu, Oana Duicu, Cristina Dehelean, Codruta Soica and Danina Muntean.

Affiliation: Department of Pharmaceutical Chemistry, "Victor Babes" University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., 300041, Timisoara, Romania.


Betulinic acid (BA), a natural compound with a lupan skeleton, has been highly investigated in the past decade for a plethora of beneficial properties, including anti-cancer, anti-inflammatory, anti-angiogenic, immune-modulatory, and anti-HIV effects. In particular, BA has been reported to be effective in vitro against tumor cell lines of different origins, and also in vivo, in animal models of cancer. The best characterized mechanism of its antitumor effect consists of triggering apoptosis via the mitochondrial pathway. BA has also an anti-metastatic effect via the prevention of the epithelial-to-mesencymal transition in highly aggressive melanoma cells. Furthermore, in the same model, BA is able to counteract the pro-invasive potential of the pro-tumoral protein neutrophil gelatinaseassociated lipocalin. The present review addresses the current state of knowledge regarding the anti-tumor effects of betulinic acid, a potent chemotherapeutic agent.


Angiogenesis, anti-tumor, betulinic acid, melanoma, mitochondria.

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Article Details

Volume: 14
Issue Number: 7
First Page: 936
Last Page: 945
Page Count: 10
DOI: 10.2174/1871520614666140223192148
Price: $58

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