Curcumin: A Promising Agent Targeting Cancer Stem Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Curcumin: A Promising Agent Targeting Cancer Stem Cells

Anti-Cancer Agents in Medicinal Chemistry, 14(6): 787-792.

Author(s): Shufei Zang, Tao Liu, Junping Shi and Liang Qiao.

Affiliation: The Affiliated Hospital of Hangzhou Normal University, NO.126, WenzhouRoad, Hangzhou 310015, Zhejiang Province, China.


Cancer stem cells are a subset of cells that are responsible for cancer initiation and relapse. They are generally resistant to the current anticancer agents. Successful anticancer therapy must consist of approaches that can target not only the differentiated cancer cells, but also cancer stem cells. Emerging evidence suggested that the dietary agent curcumin exerted its anti-cancer activities via targeting cancer stem cells of various origins such as those of colorectal cancer, pancreatic cancer, breast cancer, brain cancer, and head and neck cancer. In order to enhance the therapeutic potential of curcumin, this agent has been modified or used in combination with other agents in the experimental therapy for many cancers. In this mini-review, we discussed the effect of curcumin and its derivatives in eliminating cancer stem cells and the possible underlying mechanisms.


Cancer stem cells, combination, curcumin, microRNA, therapy.

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Article Details

Volume: 14
Issue Number: 6
First Page: 787
Last Page: 792
Page Count: 6
DOI: 10.2174/1871520614666140521114735
Price: $58

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