Novel Mechanisms of Anticancer Activities of Green Tea Component Epigallocatechin- 3-Gallate

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Novel Mechanisms of Anticancer Activities of Green Tea Component Epigallocatechin- 3-Gallate



Anti-Cancer Agents in Medicinal Chemistry, 14(6): 779-786.

Author(s): Le Zhang, Yaqing Wei and Jinsong Zhang.

Affiliation: Key Laboratory of Tea Biochemistry and Biotechnology, Anhui Agricultural University of China, 130 West Changjiang Rd., Hefei 230036, Anhui, PR China.

Abstract

After water, tea is the most widely consumed beverage. The major active constituents in green tea are catechins, of which epigallocatechin-3-gallate (EGCG) is the most abundant and active compound. Animal experimental studies using EGCG alone or green tea catechins with EGCG being a major component have generated a mounting body of evidence suggesting that EGCG as a naturally occurring compound and commonly consumed beverage ingredient is a promising cancer preventive agent. However, the relationship between green tea consumption and reduced cancer risk seen from epidemiologic studies is not as encouraging as that observed in animal studies and remains inconclusive. In the present article, the achievements using EGCG or green tea catechins for cancer prevention were reviewed, the latest identified anticancer mechanisms of EGCG and the emerging mechanism-based cancer therapies of EGCG were outlined, and the potential reasons for the discrepancy in animal studies and epidemiological studies were tentatively analysed. On the basis of these analyses, it could be anticipated that future intervention trials in humans would be able to achieve consistent cancer prevention effects provided that the timely intervention of EGCG or green tea catechins at appropriate high-dose levels presumably approaching their upper safety limits have had been fully considered.

Keywords:

Cancer prevention, cancer therapy, epigallocatechin-3-gallate, 67-kDa laminin receptor, thioredoxin system, tea.



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Article Details

Volume: 14
Issue Number: 6
First Page: 779
Last Page: 786
Page Count: 8
DOI: 10.2174/1871520614666140521114327
Price: $58
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