Damnacanthal: A Promising Compound as a Medicinal Anthraquinone

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Damnacanthal: A Promising Compound as a Medicinal Anthraquinone



Anti-Cancer Agents in Medicinal Chemistry, 14(5): 750-755.

Author(s): Nadiah Abu, Norlaily Mohd Ali, Wan Yong Ho, Swee Keong Yeap, Muhammad Yusran Abdul Aziz and Noorjahan Banu Alitheen.

Affiliation: Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia.

Abstract

The Noni fruit, or scientifically known as Morinda citrifolia can be found in various parts of the world, especially in the pacific region. It is a small evergreen bushy-like tree originated from the Rubiaceae family. The plant has been used by polynesians as a medicinal herb for more than 2000 years. A substantial amount of phytochemicals can be found in the roots of this plant. Among all, damnacanthal has been found to be the most interesting, versatile and potent compound. Damnacanthal or chemically known as,3- hydroxy-1-methoxyanthraquinone-2-caboxaldehyde (C16H10O5), appears as pale yellow crystals with a melting point of 210-211 °C. This compound is of particular interest due to its striking pharmacological properties. Damnacanthal was shown to inhibit the oncogene Ras, p56lck tyrosine kinase, NF-KB pathway and induce apoptosis in vitro. This review aims to discuss the biological properties of damnacanthal, specifically on its anti-cancer activity that has been reported.

Keywords:

Anti-cancer, anti-inflammation, damnacanthal, morinda citrifolia, noni, pharmacology.



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Article Details

Volume: 14
Issue Number: 5
First Page: 750
Last Page: 755
Page Count: 6
DOI: 10.2174/18715206113136660366
Price: $58
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