Recent Advances in Small Molecule Prodrugs for Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Recent Advances in Small Molecule Prodrugs for Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry, 14(3): 418-439.

Author(s): Peng Wang, Xiao Jin, Jin Cai, Junqing Chen and Min Ji.

Affiliation: School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, P.R. China.


Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.


Anticancer, cancer, prodrug, small molecule, therapy.

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Article Details

Volume: 14
Issue Number: 3
First Page: 418
Last Page: 439
Page Count: 22
DOI: 10.2174/18715206113139990317
Price: $58

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