Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives

Anti-Cancer Agents in Medicinal Chemistry, 14(10): 1397-1401.

Author(s): Brigida Immacolata Pia Schiavone, Luisella Verotta, Antonio Rosato, Muraglia Marilena, Simon Gibbons, Ezio Bombardelli, Carlo Franchini and Filomena Corbo.

Affiliation: Department of Chemistry, University of Milan, via Golgi 19, 20133 Milan, Italy.


Hyperforin is a natural phloroglucinol that has been known for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.


Anti-angiogenic, antibacterial, anticancer, biofilm, hyperforin, hyperforin-derivatives, proapoptotic.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1397
Last Page: 1401
Page Count: 5
DOI: 10.2174/1871520614999140829122803
Price: $58

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