The Interactions of Anticancer Agents with Tea Catechins: Current Evidence from Preclinical Studies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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The Interactions of Anticancer Agents with Tea Catechins: Current Evidence from Preclinical Studies



Anti-Cancer Agents in Medicinal Chemistry, 14(10): 1343-1350.

Author(s): Weihu Shang, Weidong Lu, Mei Han and Jinping Qiao.

Affiliation: Key Lab of Radiopharmaceutical Chemistry, Ministry of Education, College of Chemistry, Beijing Normal University, No.19 Xin Jie Kou Wai Avenue, HaiDian District, Beijing 100875, P.R.China.

Abstract

Tea catechins exhibit a broad range of pharmacological activities that impart beneficial effects on human health. Epigallocatechin-3-gallate (EGCG), one of the major tea catechins, has been widely associated with cancer prevention and treatment. In addition, tea catechins in combination with anticancer drugs are being evaluated as a new cancer treatment strategy. However, the interactions of anticancer drugs with tea catechins are largely unknown. Accumulated data indicate significant interactions between anticancer drugs and tea catechins, such as synergistic tumor inhibition or antagonist activity. Therefore, it is critical to understand comprehensively the effects of tea catechins on anticancer drugs. Focusing on evidence from preclinical studies, this paper will review the interactions between anticancer drugs and tea catechins, including pharmacodynamics and pharmacokinetics effects. We hope that by detailing the interactions between anticancer drugs and tea catechins, more attention will be directed to this important therapeutic combination in the future.




Keywords:

Drug interactions, EGCG, pharmacodynamics, pharmacokinetics, tea catechins.



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Article Details

Volume: 14
Issue Number: 10
First Page: 1343
Last Page: 1350
Page Count: 8
DOI: 10.2174/1871520614666140829123651
Price: $58
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