Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17



Anti-Cancer Agents in Medicinal Chemistry, 14(1): 66-76.

Author(s): Tatyana. A Sushko, Andrei A. Gilep and Sergey A Usanov.

Affiliation: Institute of Bioorganic Chemistry NASB Belarus, 220141 Minsk, Kuprevicha str. 5/2, Belarus.

Abstract

Most prostate and breast cancers are hormone dependent. The inhibition of steroid 17α-hydroxylase/17,20- lyase (CYP17), which is a crucial enzyme for steroid hormone biosynthesis, is widely used to treat androgen-dependent prostate cancer (PC). CYP17 has dual enzymatic activity: 17alpha-hydroxylase activity (utilizing delta4- C21 steroids as substrates) and the 17,20-lyase activity (using delta5- C21 steroids as substrates). The steroid biosynthetic pathway is directed to either the production of corticosteroids or sex hormones depending on the activity of CYP17. In this review, the current information on the genetics, molecular structure, substrate specificity and inhibitors of CYP17 is analyzed and discussed.

Keywords:

Cytochrome P450, CYP17, hormone-dependent cancer, inhibitors of androgen biosynthesis, prostate cancer, steroid hormone biosynthesis, steroid 17α-hydroxylase, 17, 20-lyase.



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Article Details

Volume: 14
Issue Number: 1
First Page: 66
Last Page: 76
Page Count: 11
DOI: 10.2174/187152061131300330
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