Management Of Elderly Patients With Diffuse Large B-Cell Lymphomas

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Management Of Elderly Patients With Diffuse Large B-Cell Lymphomas



Anti-Cancer Agents in Medicinal Chemistry, 13(9): 1412-1418.

Author(s): Rosanna Ciancia, Umberto Tirelli, Josep-Maria Ribera and Michele Spina.

Affiliation: Division of Medical Oncology A, National Cancer Institute of Aviano, Via Franco Gallini 2, 33081 Aviano (PN), Italy

Abstract

Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will triple by the year 2030. With the increase of the geriatric population, there is a need for the development and validation of treatment strategies for NHL for these patients. Therapy in elderly patients needs special attention because older patients usually suffered of several co-morbidities and their management represents a challenge for physicians. In fact, older patients treated for lymphoma may not tolerate the high-dose therapies used in younger patients and have increased risk of therapy-related toxicity as a result of age-related physiological changes and frequent co-morbidities. The widespread use of a comprehensive geriatric assessment tool might overcome the difficulty to run prospective clinical trial in elderly patients with lymphoma.

Keywords:

Elderly patients, lymphoma, comprehensive geriatric assessment, therapy related toxicity.



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Article Details

Volume: 13
Issue Number: 9
First Page: 1412
Last Page: 1418
Page Count: 7
DOI: 10.2174/18715206113136660363
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