Omega-3 Polyunsaturated Fatty Acids and Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Omega-3 Polyunsaturated Fatty Acids and Cancer



Anti-Cancer Agents in Medicinal Chemistry, 13(8): 1162-1177.

Author(s): Kaipeng Jing, Tong Wu and Kyu Lim.

Affiliation: Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, 301-747, Korea.

Abstract

While the anticancer effect of omega-3 polyunsaturated fatty acids (omega-3 fatty acids), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been the subject of intense study, our understanding regarding the underlying mechanisms of omega-3 fatty acids against cancer is still limited. Recent studies describing the cancer protective effect of EPA and DHA have sparked a renewed interest in using these fatty acids for cancer prevention and treatment. Here, we summarize the significance of omega- 3 fatty acids in the initiation and progression of cancer, and review the complex mechanisms by which EPA and DHA are thought to have anticancer activities during cancer development. It is concluded that omega-3 fatty acids may exert their anticancer actions by influencing multiple targets implicated in various stages of cancer development, including cell proliferation, cell survival, angiogenesis, inflammation, metastasis and epigenetic abnormalities that are crucial to the onset and progression of cancer.

Keywords:

Apoptosis, autophagy, cancer development, cancer prevention, docosahexaenoic acid, eicosapentaenoic acid, epigenetic regulation, omega-3 polyunsaturated fatty acid.



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Article Details

Volume: 13
Issue Number: 8
First Page: 1162
Last Page: 1177
Page Count: 16
DOI: 10.2174/18715206113139990319
Price: $58
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