Sugar-Borate Esters – Potential Chemical Agents in Prostate Cancer Chemoprevention

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Sugar-Borate Esters – Potential Chemical Agents in Prostate Cancer Chemoprevention



Anti-Cancer Agents in Medicinal Chemistry, 13(6): 901-909.

Author(s): Romulus Ion Scorei and Radu Popa.

Affiliation: University Park Campus, ZHS 117, Mail Code 0740, University of Southern California, Los Angeles, 90089- 0740 CA USA.

Abstract

The potential value of sugar-borate esters (SBEs) in the chemo-preventive therapy of prostate cancer has been reviewed. We propose that SBEs act as boron (B) vehicles, increasing the concentration of borate inside cancer cells relative to normal cells. Increased intracellular concentration of borate activates borate transporters, but also leads to growth inhibition and apoptosis. The effects of SBEs on normal cells are less dramatic because SBEs are naturally-occurring biochemicals, common and abundant in some fruits and vegetables, and also because borate dissociated from SBEs in natural diet doses is easily exported from normal cells. Cancer cell lines that over-express sugar transporters or under-express borate export are potential targets for SBE-based therapy. With regard to efficiency against cancer cells and drug preparation requirements, trigonal cis-diol boric monoesters will be one of the most effective class of SBEs. Because negative correlation exists between borate intake and the incidence of prostate cancer, and because most cancer cells overexpress sugar transporters, SBEs are proposed as a potential chemopreventive avenue in the fight against primary and recurrent prostate cancer.

Keywords:

Boron, sugar-borate esters, prostate cancer, chemoprevention, diet, ribose, fructose, sugar transport.



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Article Details

Volume: 13
Issue Number: 6
First Page: 901
Last Page: 909
Page Count: 9
DOI: 10.2174/18715206113139990124
Price: $58
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