Multidisciplinary Approach to Patient with Malignant Melanoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Multidisciplinary Approach to Patient with Malignant Melanoma

Anti-Cancer Agents in Medicinal Chemistry, 13(6): 887-900.

Author(s): Giuseppina Della Vittoria Scarpati, Celeste Fusciello, Francesco Sabbatino, Soldano Ferrone, Francesco Caponigro, Francesco Perri, Chiara Carlomagno and Stefano Pepe.

Affiliation: Department of Medicine, University of Salerno and Division of Oncology, “San Giovanni di Dio e Ruggi d’Aragona” Hospital, Salerno.


The incidence of melanoma is rapidly increasing worldwide and the prognosis of patients with metastatic disease is still poor, with a median survival of 8–9 months and a 3-year overall survival (OS) rate less than 15% [1,2].

A complete surgical excision is the main treatment for primary cutaneous melanoma [3], but controversies about the extension of excision margins still remain [4].

Sentinel lymph node biopsy (SLNB) provides important prognostic and staging data by the identification of regional node-negative patients who would not benefit from a complete nodal dissection. However, there is no consensus in the definition of melanoma thickness to enforce the execution of the SLNB [5].

To date, Interferon-α (IFN-α)is the only approved adjuvant treatment after surgical excision of high-risk melanoma, but its indication remains still controversial [2,6].


Melanoma, immunotherapy, B-RAF inibithors, chemotherapy.

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Article Details

Volume: 13
Issue Number: 6
First Page: 887
Last Page: 900
Page Count: 14
DOI: 10.2174/18715206113139990079
Price: $58

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