Heterocyclic Chalcone Analogues as Potential Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Heterocyclic Chalcone Analogues as Potential Anticancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 13(3): 422-432.

Author(s): Vikas Sharma, Vipin Kumar and Pradeep Kumar.

Affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.

Abstract

Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two aromatic rings joined by a three-carbon α,β-unsaturated carbonyl system, various synthetic compounds possessing heterocyclic rings like pyrazole, indole etc. are well known and proved to be effective anticancer agents. In addition to their use as anticancer agents in cancer cell lines, heterocyclic analogues are reported to be effective even against resistant cell lines. In this connection, we hereby highlight the potential of various heterocyclic chalcone analogues as anticancer agents with a brief summary about therapeutic potential of chalcones, mechanism of anticancer action of various chalcone analogues, and current and future prospects related to the chalcones-derived anticancer research. Furthermore, some key points regarding chalcone analogues have been reviewed by analyzing their medicinal properties.

Keywords:

Anticancer agents, Chalcone analogues, Heterocyclic chalcone analogues, indolyl chalcones, synthesized novel chalcone linked imidazolones, pyridyl chalcones, coumarin chalcone, ferrocene, glioblastoma, pyrazolic chalcones .



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Article Details

Volume: 13
Issue Number: 3
First Page: 422
Last Page: 432
Page Count: 11
DOI: 10.2174/1871520611313030006
Price: $58
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