Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy



Anti-Cancer Agents in Medicinal Chemistry, 13(3): 403-413.

Author(s): Hao Li, Jianhao Wang, Gang Huang, Ping Wang, Rongqin Zheng, Chao Zhang and Qing Jiang.

Affiliation: School of Engineering, Sun Yat-Sen University, Guangzhou 510006, P. R. China.

Abstract

Microbubbles (MBs) are gas-filled hollow microparticles. Under the ultrasound field, the difference of acoustic characteristics between gas and plasma in the blood vessel will cause strong impedance mismatch and echogenicity to enhance ultrasonic grey scale imaging. The linear or nonlinear resonance of MB shell in the ultrasound field would lead to repeated expansion-contraction till destruction. In this case, the pre-loaded drug in the MB shell will be released in an accelerated manner triggered by the ultrasound at a probe–given site. Sonoporation effect of the cell membrane would also help increase the uptake of substances into cells. This paper is dedicated to review recent developments on MBs, especially multifunctionalized MBs, as a potential drug/gene delivery microdevices for both diagnosis and therapy of malignant tumors.

Keywords:

Microbubbles, Multifunctionalization, Cancer diagnosis, Cancer therapy, Contrast-enhanced ultrasonic imaging, Drug delivery system, Tumor-targeting, prostatectomy tissues, Phospholipid Microbubbles.



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Article Details

Volume: 13
Issue Number: 3
First Page: 403
Last Page: 413
Page Count: 11
DOI: 10.2174/1871520611313030004
Price: $58
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