Conventional Chemotherapy and Emerging Targeted Therapy for Advanced Adrenocortical Carcinoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Conventional Chemotherapy and Emerging Targeted Therapy for Advanced Adrenocortical Carcinoma



Anti-Cancer Agents in Medicinal Chemistry, 13(2): 248-253.

Author(s): Yun-Ze Xu and Yu Zhu.

Affiliation: Department of Urology, Shanghai Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, No.197, Ruijin Er Road, Shanghai, 200025, China.

Abstract

Adrenocortical carcinoma (ACC) is a rare but typically aggressive malignancy. Radical surgery remains the potentially curative option. However, about one third of patients initially present with distant metastases. Regarding to chemotherapy, mitotane alone or in combination with cytotoxic drugs should be the first selection. Meanwhile, a phase lll clinical trial of etoposide, doxorubicin, cisplatin plus mitotane or streptozotocin plus mitotane is currently undergoing worldwide. The study on molecular pathogenesis of ACC is progressing. A lot of targeted therapies are also enrolled in preclinical investigations and clinical trials, including small-molecule tyrosine kinase inhibitors, antiangiogenic compounds. This article introduced the conventional chemotherapy, newly developed targeted therapy for advanced ACC.

Keywords:

Advanced adrenocortical carcinoma, Chemotherapy, Mitotane, Molecular target, Target therapy .



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Article Details

Volume: 13
Issue Number: 2
First Page: 248
Last Page: 253
Page Count: 6
DOI: 10.2174/1871520611313020010
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