Functional Nanoplatforms for Enhancement of Chemotherapeutic Index

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Functional Nanoplatforms for Enhancement of Chemotherapeutic Index



Anti-Cancer Agents in Medicinal Chemistry, 13(2): 212-221.

Author(s): Jaemoon Yang, Eugene Lee, Minhee Ku, Yong-Min Huh and Jae-Ho Cheong.

Affiliation: Department of Surgery, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea.

Abstract

Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

Keywords:

Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect.



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Article Details

Volume: 13
Issue Number: 2
First Page: 212
Last Page: 221
Page Count: 10
DOI: 10.2174/1871520611313020005
Price: $58
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