Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines



Anti-Cancer Agents in Medicinal Chemistry, 13(10): 1582-1589.

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M M Pinto.

Affiliation: CEQUIMED-UP/CEQOFFUP – Centro de Estudos de Quimica, Medicinal, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal, Departamento de Ciencias Quimicas, Laboratorio de Quimica Organica e Farmaceutica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal.

Abstract

Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.

Keywords:

Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.



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Article Details

Volume: 13
Issue Number: 10
First Page: 1582
Last Page: 1589
Page Count: 8
DOI: 10.2174/1871520613666131125122857
Price: $58
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