Anti-cancer Effects of Curcumin on Head and Neck Cancers

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Anti-cancer Effects of Curcumin on Head and Neck Cancers



Anti-Cancer Agents in Medicinal Chemistry, 12(9): 1110-1116.

Author(s): Wei Gao, Jimmy Yu-Wai Chan, William Ignance Wei and Thian-Sze Wong.

Affiliation: Department of Surgery, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR China.

Abstract

Head and neck cancer is the sixth large type of cancer in the world. The treatment regimens for head and neck cancer encompass surgery, radiotherapy and chemotherapy. However, all current treatment regimens for head and neck cancer have adverse effects. Therefore, continuing investigations have been undertaken to seek less toxic therapies to reduce treatment morbidity for head and neck cancer. Substantial evidence has demonstrated that curcumin inhibited proliferation, migration, invasion and metastasis and induced apoptosis via modulating multiple signaling pathways in head and neck cancer. Curcumin also suppressed the growth of xenograft derived from head and neck cancer in vivo in animal models. This review summarizes the evidence demonstrating potential use of curcumin as a single chemotherapeutic agent or in combination with other chemotherapeutic agents and radiation to minimize their toxicity in head and neck cancer. Although curcumin has been shown to be safe at doses of 8 g/d in both phase I and phase II clinical trials, its bioavailability is poor. Overcoming the poor bioavailability of curcumin in the near future would facilitate its clinical use.

Keywords:

Chemotherapeutic agent, Curcumin, Epigenetics regulation, Head and neck cancer, Matrix Metalloproteinases, Signaling Pathway, Family Proteins, Cyclins/cyclin-dependent Kinases, Animal Xenograft, PHARMACOKINETIC.



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Article Details

Volume: 12
Issue Number: 9
First Page: 1110
Last Page: 1116
Page Count: 7
DOI: 10.2174/187152012803529736
Price: $58
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