CCR5 as a Potential Target in Cancer Therapy: Inhibition or Stimulation?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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CCR5 as a Potential Target in Cancer Therapy: Inhibition or Stimulation?

Anti-Cancer Agents in Medicinal Chemistry, 12(9): 1045-1057.

Author(s): Alicia Gonzalez-Martin, Emilia Mira and Santos Manes.

Affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnologia CNB/CSIC, Darwin 3, Campus Cantoblanco, E-28049 Madrid, Spain.


Extensive evidence implicates CCR5 and its ligands in the biology of tumors, although there is considerable controversy regarding the role of this chemokine receptor in cancer progression. The discrepancies between the pro- and anti-tumor effects of CCR5 might derive from its expression by cell types with opposing functions in tumor progression and the context in which tumors originate. We propose that CCR5 is necessary for optimal activation of the adaptive immune response to tumors, and for the success of certain immunotherapeutic strategies. Since efficient activation of T cell responses has broad implications in the success of some chemoand radiotherapy protocols, activation of CCR5, rather than its inhibition, might provide new therapeutic opportunities for cancer treatment.


CCR5, Chemokines, Crosspriming, Immune Response, Immunotherapy, Inflammation, Maraviroc, Tumor microenvironment, CHEMOATTRACTANT CYTOKINES, PRO-TUMOR.

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Article Details

Volume: 12
Issue Number: 9
First Page: 1045
Last Page: 1057
Page Count: 13
DOI: 10.2174/187152012803529637
Price: $58

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