Polyphenols Counteract Tumor Cell Chemoresistance Conferred by Multidrug Resistance Proteins

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Polyphenols Counteract Tumor Cell Chemoresistance Conferred by Multidrug Resistance Proteins



Anti-Cancer Agents in Medicinal Chemistry, 12(8): 880-890.

Author(s): Krystyna Michalak and Olga Wesolowska.

Affiliation: Wrocław Medical University, Department of Biophysics, ul. Chałubinskiego 10, 50-368 Wrocław, Poland.

Abstract

One of the main reasons of cancer resistance to chemotherapeutic treatment is the presence of different ABC multidrug transporters in plasma membranes. The transporters extrude wide spectrum of anticancer agents out of cancer cells at the expense of energy derived from ATP-hydrolysis. Plant-origin polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-glycoprotein, MRP1 and BCRP. The recent studies on different resistant cancer cell lines enabled the discovery of a number of polyphenolic compounds able to reverse drug resistance in vitro and these compounds could be promising candidates for further clinical trials. The review summarizes the recent advances in the field of polyphenols interaction with ATP-binding cassette multidrug transporters. The mechanism of flavonoids interactions with the multidrug transporters and the structure-activity relationship are also discussed.

Keywords:

ABC transporters, Breast cancer resistance protein (BCRP), Flavonoids, Multidrug resistance (MDR), MDR modulators, MDR reversal, Multidrug resistance-associated protein 1 (MRP1), P-glycoprotein (P-gp), Polyphenols, Stilbenes.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 12
Issue Number: 8
First Page: 880
Last Page: 890
Page Count: 11
DOI: 10.2174/187152012802650011
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science