Modulation of MMPs by Cell Surface Integrin Receptor α5β1

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Modulation of MMPs by Cell Surface Integrin Receptor α5β1

Anti-Cancer Agents in Medicinal Chemistry, 12(7): 726-732.

Author(s): Sekhar Pal, Kirat Kumar Ganguly, Shuvojit Moulik and Amitava Chatterjee.

Affiliation: Department of Receptor Biology & Tumor Metastasis, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata – 700 026, West Bengal, India.


MMPs are a family of Zn dependent endopeptidases, which can mediate degradation of ECM components during various physiological and pathological processes including cancer. Some ECM components, through interaction with integrin receptor and modulation of downstream signaling, are capable of regulating expression and activity of several MMPs. α5β1 integrin is the universally accepted receptor for the ECM component fibronectin (FN). The present review deals with the downstream signaling involved in the α5β1 integrin mediated modulation of expression and activity of MMPs and their effector responses in different cellular system.


ECM, Fibronectin, Integrin, MMP, extracellular matrix, matrix metalloproteinase, membrane-type-1 MMP, tissue inhibitor of metalloproteinases, focal adhesion kinase, phosphatidyl-inositol-3-kinase, mitogen activated protein kinase, extracellular regulated kinase.

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Article Details

Volume: 12
Issue Number: 7
First Page: 726
Last Page: 732
Page Count: 7
DOI: 10.2174/187152012802650183
Price: $58

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