Inhibiting Matrix Metalloproteinases, an Old Story with New Potentials for Cancer Treatment

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Inhibiting Matrix Metalloproteinases, an Old Story with New Potentials for Cancer Treatment



Anti-Cancer Agents in Medicinal Chemistry, 12(7): 707-717.

Author(s): Dimitris Stellas and Evangelia Patsavoudi.

Affiliation: Department of Biochemistry, Hellenic Pasteur Institute, 127, Vas. Sofias Av.,11521 Athens, Greece.

Abstract

Five decades of extensive research have passed since the description for the first time of the existence of an enzyme, which had the ability to degrade collagen during the metamorphosis of tadpoles. In fact, during these years, a large family of enzymes possessing the unique ability of degrading the extra cellular matrix (ECM) has been discovered. These enzymes are widely known as Matrix Metalloproteinases (MMPs) and it is noteworthy that many members of this family are directly linked to several human diseases such as arthritis and cancer. Moreover, due to the critical role of certain members of MMPs in cancer invasion and metastasis, great efforts have been made in order to find new inhibitory compounds against these MMPs. In this work we attempt to summarize the current status of the intervention strategies against MMPs, using inhibitory compounds that could block the activation of MMPs directly or indirectly. Furthermore we will try to shed light towards new potential strategies of MMP inhibitors using monoclonal antibodies.

Keywords:

Matrix metalloproteinases, Cancer, Monoclonal antibodies, Inhibitors, tissue inhibitors of matrix metalloproteinases, hemopexin-like, propeptide, glycosylphosphatidylinositol, melanoma cell, angiogenesis.



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Article Details

Volume: 12
Issue Number: 7
First Page: 707
Last Page: 717
Page Count: 11
DOI: 10.2174/187152012802650246
Price: $58
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