The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis

Anti-Cancer Agents in Medicinal Chemistry, 12(6): 631-639.

Author(s): Tao Shen and Shile Huang.

Affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.


Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin-dependent kinases (CDKs), such as CDK2, CDK4, and CDK6, and positively regulates the activities of CDKs that lead to cell cycle progression. In addition, Cdc25A also acts as a regulator of apoptosis. Overexpression of Cdc25A promotes tumorigenesis, and is frequently observed in various types of cancer. Here we briefly summarize current understanding of the role of Cdc25A in cell proliferation and apoptosis, as well as the impact of overexpression of Cdc25A on tumorigenesis.


Apoptosis, Cancer, Cdc25A, Cell cycle, Cell proliferation.

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Article Details

Volume: 12
Issue Number: 6
First Page: 631
Last Page: 639
Page Count: 9
DOI: 10.2174/187152012800617678
Price: $58

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