Chemoprevention of Breast Cancer by Dietary Compounds

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Chemoprevention of Breast Cancer by Dietary Compounds

Anti-Cancer Agents in Medicinal Chemistry, 12(10): 1185-1202.

Author(s): Aditi S. Vadodkar, Suman Suman, Rajkumar Lakshmanaswamy and Chendil Damodaran.

Affiliation: Center of Excellence in Cancer Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905.


Breast cancer is the leading cause of cancer-related deaths in women in the United States and many other countries. There is an immediate need for more effective and less toxic therapeutic and preventive strategies for many cancers, especially for breast cancer. Natural products are being tested with a hope of identifying novel potent molecules as anticancer agents. Phytochemicals and dietary compounds have been used for the treatment of various illnesses throughout history due to their safety, low toxicity, and general availability. Currently, many active phytochemicals are in clinical trials. Preclinical and clinical studies have indicated that daily consumption of dietary phytochemicals reduces the risk of several cancers. Phytochemicals can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes, by regulating inflammatory/proliferative signaling pathways, and by inducing apoptosis. This review article describes some of the potential natural cancer preventive compounds, along with a mechanistic discussion of their interactions with key cellular signal transduction pathways as well as their contribution to the suppression of breast cancer cell growth.


Dietary agents, Anti-cancer, Molecular signaling, Metastasis, Apoptosis, Breast Cancer, Dietary Compounds, CAROTENOIDS, BETA-CAROTENE, QUERCETIN.

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Article Details

Volume: 12
Issue Number: 10
First Page: 1185
Last Page: 1202
Page Count: 18
DOI: 10.2174/187152012803833008
Price: $58

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